Chemoprevention of Intestinal Cancer by Milk Thistle Silibin.

Posted on April 29, 2010 by Dr. Gary Pack

Chemoprevention, the chemical prevention of cancer, is an important part of colorectal cancer control. This article reviews a study of the ability of silibinin, a component of milk thistle (Silybum marianum,) to prevent colon cancer in mice. Mice prone to develop colon cancer, spontaneously, were fed silibinin. The animals were tested after 13 weeks of […]

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Conditions: Angiogenesis, Apoptosis, Bladder cancer, Cancer, Colon cancer, Colorectal cancer, Familial adenoma polyposis, Lung cancer, Polyps, Prostate cancer, Skin cancer, Small intestine cancer

Supplements: Milk thistle (Silybum marianum), Silibinin

Miscellaneous: Anti-angiogenesis, Nitric oxide synthetase

VEGF, COX-2 and MVD in Condyloma Acuminatum.

Posted on October 31, 2009 by Dr. Gary Pack

Condyloma acuminata (CA) is a disease causing warts, with increased growth of new blood vessels and increased cell proliferation. This study was done to see if vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are involved in this disease process. Microvascular density (MVD) was used to evaluate the abnormal blood vessel growth seen in these […]

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Conditions: Angiogenesis, Condyloma acuminatum (venereal warts)

Supplements: DIM (diindolylmethane), Echinacea sp., Glycine, Hops (Humulus lupulus), Milk thistle (Silybum marianum), Nettles (Urtica dioica), Selenium, Zinc

Foods: Cruciferous vegetables, Green tea (Camellia sinensis)

Miscellaneous: COX-2, VEGF (vascular endothelial growth factor)

Mercury Concentrations in Food Product Sugar.

Posted on September 11, 2009 by Dr. Gary Pack

Chlor-alkali chemical plants use mercury to make products such as citric acid, sodium benzoate and high fructose corn syrup (HFCS.) There are 8 such plants in the U.S. From these plants seven tons of mercury were missing in 2000 according to the EPA (Environmental Protection Agency.) Mercury is toxic to the brains of unborn children, […]

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Conditions: Mercury poisoning, Neurodegeneration

Supplements: Citric acid (citrate), Glutathione, Milk thistle (Silybum marianum), Selenium

Foods: Fish, High fructose corn syrup, Liver, Poultry

Miscellaneous: Vaccines

Silymarin Treatment of Viral Hepatitis.

Posted on November 25, 2008 by Dr. Gary Pack

Silymarin is a component of the herb milk thistle (Silybum marianum). Silymarin is 70% of standardized milk thistle and most of silymarin is a flavonolignan called silibin. (Silibin is also known as silibinin.) Milk thistle is used to treat viral hepatitis, yet it is uncertain whether it is beneficial. This article is a review of […]

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Conditions: Alcoholic cirrhosis, Hepatitis, Hepatitis A, Hepatitis B, Hepatitis C, Liver disease, Liver toxicity, Prostate cancer, Skin cancer, Viral hepatitis

Supplements: Agrimony (Agrimonia eupatoria), Glutathione, Milk thistle (Silybum marianum), Phosphatidylcholine, Silybinin, Silymarin, Superoxide dismutase (SOD)

Miscellaneous: Flavonolignans

Milk Thistle Phytosome.

Posted on November 7, 2007 by Dr. Gary Pack

Milk thistle (Silybum marianum), an anti-oxidant, contains flavonoids that protect the liver. The liver detoxifies hormones and other chemicals produced in the body and is an easy target for damage by any toxins ingested. Silymarin is the active extract of Milk thistle which contains the following flavonoids: Silibin, silydianin and silychristin. Silibin is a flavonolignan. […]

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Conditions: Alcoholic hepatitis, Liver protection, Liver toxicity, Viral hepatitis

Supplements: Antioxidants, Bioflavonoids, Curcumin, Glutathione, Grape seed extract, Green tea, Lignans, Milk thistle (Silybum marianum), Phosphatidylcholine, Phytosomes, Silibinin, Silymarin

Foods: Soy

Miscellaneous: Phospholipids

Silymarin is Hepatoprotective in Cholestasis.

Posted on September 20, 2007 by Dr. Gary Pack

Silymarin (SIL) is an extract of Milk thistle (Silybum marianum), which has been used for 2000 years. Milk thistle has been used since the 16th century for liver disease and SIL has been marketed since 1969. SIL is a standard extract of the Milk thistle fruit and seed and standardized Milk thistle is 70% SIL. […]

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Silibinin and Hepatocellular Carcinoma.

Posted on March 6, 2007 by Dr. Gary Pack

Hepatocellular carcinoma (HCC) of the liver, which has no current effective treatment, is the world’s second most common recurrent cancer, with one million people dying of HCC annually worldwide. The treatment is poor at present because of drug resistance and the severe toxicity of the drugs used for chemotherapy. HCC cells are especially resistant to […]

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Conditions: Apoptosis, Bladder cancer, Breast cancer, Cancer, Chemotherapy, Colon cancer, Fungal infection, Hepatitis, Hepatitis B, Hepatitis C, Hepatocellular cancer, Lung cancer, Multidrug resistance (MDR), Prostate cancer, Skin cancer

Supplements: Milk thistle (Silybum marianum), Silibinin, Silymarin

Miscellaneous: Aflatoxin, Aspergillus mold, Liver

New Therapy for Age-Related Macular Degeneration.

Posted on January 25, 2007 by Dr. Gary Pack

Age-related macular degeneration (AMD) is a common cause of blindness in the elderly. New drugs are being tested to work against vascular endothelial growth factor (VEGF), a natural chemical in the body that causes neovascularization (the growth of new blood vessels) in the eye. Corticosteroids, which prevent the growth of new blood vessels, are used […]

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Conditions: Age-related macular degeneration, Angiogenesis, Blindness, Cancer, Neovascularization

Supplements: Beta-carotene, DIM (diindolylmethane), Fish oil, Glycine, Green tea extract, Lutein, Milk thistle (Silybum marianum), Selenium, Silymarin, Vitamin C (ascorbic acid), Vitamin E, Zeaxanthin, Zinc

Foods: Corn

Miscellaneous: Corticosteroids, Macula, Photodynamic therapy, VEGF (vascular endothelial growth factor)

Omega-3 and Retinal Disease.

Posted on January 13, 2007 by Dr. Gary Pack

“Ocular neovascularization (growth of new blood vessels in the eye) is the most common cause of blindness in all age groups.” Diseases with visual loss have a first stage of loss of circulation and resulting loss of oxygen to the eye and a second stage of growth of new blood vessels (angiogenesis) resulting from the […]

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Conditions: Age-related macular degeneration, Angiogenesis, Blindness, Diabetic retinopathy, Ischemic retinopathy, Neovascularization, Retinopathy

Supplements: Arginine, Docosahexanoic acid (DHA), Eicosapentanoic acid (EPA), Milk thistle (Silybum marianum), Omega-3 fatty (linolenic) acid, Omega-6 fatty (linoleic) acid

Foods: Mother's milk

Miscellaneous: Arachidonic acid

Acidic pH and Metastasis of Melanoma Cells.

Posted on December 22, 2006 by Dr. Gary Pack

Extracellular pH in many tumors has been shown to be lower, or more acidic, than in surrounding tissues. The present study was done to evaluate the role of pH in metastatic disease. Mice with metastatic melanoma to the lungs were studied. Cancer cells were cultured in acidic culture as compared to more alkaline environments.

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Conditions: Acidosis (acidity), Angiogenesis, Cancer, Chemotherapy, Melanoma, Metastases

Supplements: DIM (diindolylmethane), Glycine, Milk thistle (Silybum marianum), Proteolytic enzymes, Selenium, Zinc

Foods: Green tea (Camellia sinensis)

Miscellaneous: VEGF (vascular endothelial growth factor)