5-Lipoxygenase and Amyloid Formation in Alzheimer’s Disease.

Posted on April 20, 2015 by Dr. Gary Pack

Alzheimer’s disease (AD) is a neurodegenerative disease of the brain. In AD a tangled protein called amyloid is formed in brain cells and regulated by 5-lipoxygenase (5-LO) enzymes, which are inflammatory. This 5-LO enzyme pathway is involved in several inflammatory processes, such as arteriosclerosis, cardiovascular disease, and aging of the brain. Patients with AD have […]

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Conditions: Aging, Alzheimer's disease, Arteriosclerosis (atherosclerosis), Cardiovascular disease, Inflammation, Neurodegenerative disease

Supplements: Boswellia (Boswellia serrata), Curcumin, Milk thistle (Silybum marianum), Silymarin, Turmeric (Curcuma longa)

Miscellaneous: 5-lipoxygenase, 5-lipoxygenase inhibitors, Amyloid, Beta-amyloid, Central nervous system

Liver Protection by Herbs.

Posted on April 20, 2015 by Dr. Gary Pack

Andrographis paniculata (andrographis), Phyllanthus niruri (stone breaker), and Phyllanthus emblica (amla or Indian gooseberry) are all known to provide liver protection effects, but have not been studied in combinations. The purpose of this research was to study a combination of the three against liver damage caused by paracetamol, carbon tetrachloride (CCl4) and ethanol in rats. […]

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Conditions: Liver toxicity

Supplements: Amla (Phyllanthus emblica Linn), Amla berry, Andrographis (Andrographis paniculata), Milk thistle (Silybum marianum), Silymarin, Stone breaker (Phyllanthus niruri)

Miscellaneous: Bilirubin, Hepatoprotective

Anti-Angiogenesis Review.

Posted on May 5, 2012 by Dr. Gary Pack

Angiogenesis is a normal process of forming new blood vessels. It takes place in growth, menstrual cycles, healing, etc. It is necessary for cancers to grow and to metastasize. It occurs in macular degeneration and hinders the vision. Blockers of angiogenesis are beneficial in cancer, macular degeneration and other disease processes. Dr. Judah Folkmann studied […]

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Conditions: Angiogenesis, Cancer, Wounds

Supplements: Andrographis (Andrographis paniculata), Arginine, Asian ginseng (Panax ginseng), Benfotiamine, Bilberry (Vaccinium myrtillus), Cinnamon (Cinnamomum cassia), Copper, Docosahexanoic acid (DHA), Dong quai (Angelica sinensis, Eicosapentanoic acid (EPA), European mistletoe (Viscum album), Ginger (Zingiber officinale), Ginkgo (Ginkgo biloba), Gotu kola (Centellla asiatica), Green tea, Holy basil (Ocimum sanctum), Hops (Humulus lupulus), Licorice (Glycyrrhiza glabra), Lysine, Milk thistle (Silybum marianum), Omega-3 fatty (linolenic) acid, Proanthocyanidines, Quercetin, Red sage (Salvia miltiorrhiza), Resveratrol, Selenium, Skullcap (Scutellaria baicalensis), St. John's Wort (Hypericin perforatum), Turmeric (Curcuma longa), Vitamin D, Wormwood (Artemisia annua), Zinc

Foods: Broccoli, Brussel's sprouts, Cruciferous vegetables, Green tea (Camellia sinensis), Matcha green tea, Mate (Ilex paraguayensis)

Miscellaneous: COX-2, COX-2 inhibitor, Exercise, Folkman (Dr. Judah), Li (Dr. William), Proton pump inhibitors, Vegan

Milk Thistle, Silymarin and Hepatitis C.

Posted on June 19, 2011 by Dr. Gary Pack

Silymarin is an extract of milk thistle (Silybum marianum), in which flavonolignan chemicals in silymarin inhibit the hepatitis C virus. In spite of the large amount of research that has been done, the definite mechanism of action against hepatitis C is uncertain. Silymarin is especially useful against hepatitis C which is a global problem involving […]

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Conditions: Cirrhosis, Esophageal varices, Hepatitis, Hepatitis B, Hepatitis C, Mushroom poisoning

Supplements: Agrimony (Agrimonia eupatoria), Milk thistle (Silybum marianum), Phytoestrogens, Silibinin, Silymarin

Miscellaneous: Anti-inflammatory, Antiviral, Flavonolignans, Immunomodulatory

Milk Thistle and Silymarin Review.

Posted on June 6, 2011 by Dr. Gary Pack

Milk thistle (MT) (Silybum marianum) is an herb with a 2000 year history of use. Silymarin (SIL) is an extract of milk thistle. It consists of flavonoids and lignans. The main flavonoid is silibinin. SIL has no toxicity to the fetus before birth or to the child during breastfeeding. SIL is used, primarily, in liver […]

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Angiogenesis in Vascular and Tumor Biology.

Posted on May 22, 2011 by Dr. Gary Pack

Dr. Judah Folkman died after doing important research for 40 years on angiogenesis (the formation of new blood vessels.) He died, unexpectedly, on 14 Jan., 2008. His discoveries have changed our ideas about tumor treatment, tumor growth, and other diseases. As a young surgeon, Dr. Folkman was interested in tumor growth and invented techniques whereby […]

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Thyroid Cancer Review.

Posted on May 8, 2011 by Dr. Gary Pack

Patrick, in Summary #375 writes that thyroid disease, including cancer and autoimmune disease, is rapidly increasing. PCBs (polychlorinated biphenyl) environmental pollutants are associated with thyroid cancer. They are still in fish, even in salmon from Alaska. Patrick, in Summary #387 writes that low iodine increases cancer of the thyroid. Low iodine increases the uptake of […]

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Conditions: Angiogenesis, Autoimmune thyroiditis, Cancer, Multiple sclerosis, Thyroid cancer, Thyroid disease

Supplements: Bifidobacterium sp., DIM (diindolylmethane), Glutathione peroxidase, Glycine, Iodine, Lactobacillus species, Milk thistle (Silybum marianum), Resveratrol, Selenium, Silymarin, Zinc

Foods: Brazil nuts, Broccoli, Garlic, Leeks, Matcha green tea, Onions

Miscellaneous: Element, Histone deacetylation, Japanese diet, Natural killer (NK) cells, Prolactin, Thyroid gland

Carbonic Anhydrase Inhibitors in Natural Food Compounds.

Posted on April 25, 2011 by Dr. Gary Pack

Carbonic anhydrase (CA) is an enzyme which converts carbon dioxide (CO2) to bicarbonate and a proton (hydrogen ion.) This is necessary to many physiologic processes, such as acid-base balance, breathing, and tumor development. A number of CA forms are targets for inhibition in treatment of cancer, edema, glaucoma, obesity, epilepsy, and osteoporosis. Resveratrol, catechin, silymarin, […]

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Conditions: Acid-base balance, Cancer, Edema, Epilepsy, Glaucoma, Obesity, Osteoporosis

Supplements: Curcumin, EGCG (epigallocatechin gallate), Milk thistle (Silybum marianum), Resveratrol, Silymarin

Foods: Red wine, Tea

Miscellaneous: Carbonic anhydrase, Hydrogen, Polyphenols, Sulfonamide

Liver Protection Activity of Virgin Coconut Oil.

Posted on March 27, 2011 by Dr. Gary Pack

Coconut oil (CO) has been known for centuries to have health benefits and is now seen as a functional food. Virgin CO (VCO) is antioxidant, antimicrobial, antiviral, antihypercholesterol and antithrombotic. Cold processing of VCO conserves the chemicals of coconuts, tocopherols, sterols, and squalene. It is 48-50% saturated medium chain fatty acid (lauric oil) and short […]

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Phytosome Complexes of Silymarin, Curcumin, Etc.

Posted on August 9, 2010 by Dr. Gary Pack

One class of very useful plant medicines is made up of polyphenols, mostly flavonoids. Polyphenols absorb poorly into water or lipids. The phytosome forms of polyphenols have improved oral absorption and are safe. They are used as anti-inflammatories, anti-neoplastics, for detoxification and for weight loss.Polyphenols bind strongly to phospholipids, even in intact plant tissue. Phosphatidylcholine […]

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