Depression commonly causes chronic stimulation of the Hypophyseal-Pituitary-Adrenal (HPA) axis with over-secretion of ACTH and cortisol. The author’s previously showed that both an alcohol extract of St. John’s Wort (Hypericum perforatum) and hypericin, a constituent of St. John’s Wort, reduced the activity of the HPA axis. (Hyperforin was inactive in reducing HPA stimulation.) The present […]
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