5-Alpha Reductase Inhibitors and Benign Prostatic Hyperplasia.

Posted on April 20, 2015 by Dr. Gary Pack

Most common lower urinary tract symptoms in post-middle aged males are due to benign prostate enlargement. Pharmacological treatments include *alpha blockers and 5-alpha reductase inhibitors (5ARIs). 5ARIs have been shown to reduce the size of the prostate gland. 5ARIs block the transformation of testosterone into dehyrotestosterone, an attempt to prevent division of the cells in […]

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Conditions: Benign prostatic hypertrophy, Bladder outlet obstruction

Supplements: Gegen (kudzu), Kudzu (Pueraria lobata), Saw palmetto (Serenoa repens)

Miscellaneous: 5-alpha reductase, 5-alpha reductase inhibitor, Alpha blocker, Finasteride, Muscle, Prostate, Testosterone, Urinary bladder, Urinary system

Copper, Cardiovascular Disease and Diabetes.

Posted on March 22, 2015 by Dr. Gary Pack

Copper is an essential trace mineral for the human body. Of the 110 mg. in a 70 kg person, 46 mg. is in the bone. Copper-dependent transport systems are important for iron and zinc to be delivered to different parts of the body. In spite of the importance of copper, copper-containing pharmaceuticals* have not been […]

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Conditions: Cardiovascular disease, Diabetes

Supplements: Copper, Iron, Trace elements, Zinc

Foods: Glucose

Miscellaneous: Alpha-glucosidase, Antidiabetic, Bile, Bone, Brain, Kidney, Liver, Metalloproteinase, Muscle, Reactive oxygen species, Red blood cells

Thyroid Dysfunction and the Lipid Profile.

Posted on January 23, 2014 by Dr. Gary Pack

Abnormal thyroid activity can change serum lipids and other risk factors for cardiovascular disease. Low thyroid activity (hypothyroidism) can raise serum lipids, and treatment can return them to normal. However, hyperthyroidism can be associated with low serum cholesterol also. Thyroid hormone increases cholesterol production and insulin resistance. People with high anti-thyroid antibodies can have high […]

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Resveratrol and Cancer.

Posted on July 12, 2013 by Dr. Gary Pack

Resveratrol (Rsv) is a polyphenol found in grape skin, red wine, bilberries, blackberries and other foods. Resveratrol is chemopreventive of some cancers, atherosclerosis, aging and inflammatory diseases. The researchers studied the effects of Rsv on a line of heart muscle tumor cells from mice. Cancers of heart muscles are rare, but cannot be removed easily. […]

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Conditions: Aging, Apoptosis, Arteriosclerosis (atherosclerosis), Cancer, Cell death, Chemotherapy, Heart disease, Heart muscle cancer, Inflammation, Irradiation

Supplements: Resveratrol

Foods: Bilberry, Blackberry, Functional food, Grapes, Red wine

Miscellaneous: Chemoprevention, Muscle, Neurotransmitters, Norepinephrine, Nutraceuticals, Polyphenols

Whey Protein and Metabolic Diseases.

Posted on October 13, 2012 by Dr. Gary Pack

To read the author’s abstract of the article, click on the title of the article. Then, to read the full article, click on the full text icon. KEY WORDS: Anorectic hormones, Blood pressure, Body weight, Cholecystokinin, Diabetes mellitus, Diet, Ghrelin, Glucagon like peptide 1, Glucose tolerance, Inflammation, Leptin, Metabolic Disease, Muscle mass, Obesity, Oxidative stress, […]

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Conditions: Anorexia, Blood pressure, Diabetes, Inflammation, Muscle mass, Obesity, Oxidative stress, Weight loss

Supplements: Whey protein

Miscellaneous: Cholecystokinin, Diet, Ghrelin, Glucose tolerance, Leptin, Muscle

Aging and Carnosine.

Posted on June 28, 2012 by Dr. Gary Pack

Aging is accompanied by loss of muscle mass and function. scle fibers can be replaced with fat, levels of carnosine are reduced in muscle, and there is a reduction in ability to balance (buffer) muscle acidity. This can result in frailty, impaired balance, slow gait, and risk of falling. This loss of muscle activity is […]

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Conditions: Acidosis (acidity), Aging, Appetite, Exercise, Malnutrition, Muscle weakness

Supplements: Beta-alanine, Carnosine, Histidine

Miscellaneous: Anaerobic, Muscle

Vitamin D Deficiency and Myopathy.

Posted on August 3, 2011 by Dr. Gary Pack

Proximal weakness of the muscles of the shoulders and of the hips (proximal myopathy) may be the first sign of osteomalacia and can lead to a misdiagnosis of muscle disease instead of metabolic disease (vitamin D deficiency). For example, two cases of proximal myopathy are presented in people of South Asian origin and who are […]

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Conditions: Diabetes, Hypocalcemia, Hypoparathyroidism, Hypophosphatemia, Muscle weakness, Myopathy, Neurotoxicity, Osteomalacia, Vitamin D deficiency

Supplements: Calcium, Vitamin D

Miscellaneous: 25-dihydroxyvitamin D, Lacto-vegetarian diet, Muscle, Neuromuscular, Ovolacto-vegetarian diet, Parathyroid hormone (parathormone), Phytates (phytic acid)

Phyllanthus Niruri for Kidney Stones.

Posted on February 24, 2011 by Dr. Gary Pack

This article summarizes current medical progress in the treatment of urinary stones (urolithiasis) using Phyllanthus niruri (stone-breaker or quebra-pedras.) P. niruri interferes with stone formation at many stages. It contains over 50 chemicals, including alkaloids, flavonoids, lignans, and triterpenes. Crystals are seen in the urine of normal people. Under unknown conditions, the crystals start to […]

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Conditions: Urinary stones (urolithiasis)

Supplements: Bioflavonoids, Lignans, Stone breaker (Phyllanthus niruri)

Miscellaneous: Alkaloids, Calcium oxylate, Muscle, Phyllanthus amaurus, Triterpenes, Uricosuric, Urinary system, Xanthine oxidase, Xanthine oxidase inhibitors

D-Ribose in Cardiovascular Diseases.

Posted on February 7, 2011 by Dr. Gary Pack

Cardiovascular disease (CVD) is the number one cause of death, worldwide. In CVD, there is reduced circulation to the heart muscle causing reduced energy levels in the heart muscle cells. The heart is said to be “energy starved.” This changes the cells’ ability to function. No good drugs have been developed to treat this. D-ribose […]

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Conditions: Cardiovascular disease, Congestive heart failure, Death

Supplements: D-Ribose

Miscellaneous: Muscle, Potassium bicarbonate

Muscle Disease from Red Yeast Rice and Liquorice (Licorice.)

Posted on December 7, 2010 by Dr. Gary Pack

Statin drugs are the drugs most commonly known to cause myopathy (a muscle wasting disease) at this time. Neuroleptics, proton pump inhibitors, gabapentin and chemicals from medicinal plants can cause myopathy. This study reviewed an Italian database of natural products to further learn about the hazards of using herbal medicines. The Naranjo probability scale was […]

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Conditions: Hypernatremia (high sodium), Hypertension, Myopathy, Rhabdomyolysis, Statin toxicity

Supplements: Gabapentin, Licorice (Glycyrrhiza glabra), Red yeast rice (Monascus purpureus)

Miscellaneous: Creatinine phosphokinase (CPK), Herbal medicine, Monacolin K, Muscle, Proton pump inhibitors, Statin drugs

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