Dopamine, Addiction and Parkinsonism.

Posted on February 10, 2017 by Dr. Gary Pack

Dopamine (DA) neurotransmitter is reduced in a part of the brain (nucleus accumbens) in people with addictive behavior. This also occurs in animal models of drug-dependency to alcohol, opiates and cannabinoids. In human brain imaging studies of addicts to cocaine, heroin and alcohol, there is reduced production of DA in the brain. There is reduced […]

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Dopamine Hypothesis of Addiction.

Posted on July 31, 2012 by Dr. Gary Pack

Dopamine (DA), a neurotransmitter*, is involved with brain activity in drug abuse and other addictions. The activity of DA neurons in the brain is reduced in alcohol, opiate and cannabinoid-dependent rats. DA activity is depressed in an area of the brain called the nucleus accumbens in drug-dependent rodents. These deficiencies contribute to the ‘dopamine-impoverished brain’ […]

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Pregnancy, Prolactin and White Matter Regeneration.

Posted on November 19, 2010 by Dr. Gary Pack

There is a search for chemicals, oral or injectable, which will cross the blood-brain barrier to the brain to support brain repair. The authors have reported the benefits of prolactin (PRL) and luteinizing hormone on the development of new neurons (neurogenesis.) The present report is on the benefit of PRL in pregnancy on neurogenesis and […]

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Prolactinoma Masked by a Herbal Remedy.

Posted on May 4, 2010 by Dr. Gary Pack

The authors report a patient who came to a women’s clinic with signs of a prolactin producing brain tumor of the pituitary. When she first came to the women’s clinic, she had a history of infrequent menstrual periods leading to amenorrhea (absence of periods). Her breasts began producing milk, although she was not pregnant (galactorrhea.) […]

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Conditions: Amennorrhea, Galactorrhea, Pituitary adenoma, Prolactinoma

Supplements: Boswellia (Boswellia serrata), Chasteberry (Vitex agnus castus), Phenylalanine, Tyrosine

Miscellaneous: Dopamine agonists, Pituitary gland, Prolactin

Vitex agnus Castus and Prolactinoma.

Posted on May 4, 2010 by Dr. Gary Pack

This article is a response to the article by Gallagher, J., et al, who wrote the article described by Summary 382. That article reviewed the case of a girl with a prolactinoma who improved on an herb, Vitex agnus casti (chasteberry.) This herb is traditionally used for “dysmenorrhea, oligo/amenorrhea, premenstrual syndrome, corpus luteum insufficiency, infertility, […]

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Conditions: Amennorrhea, Galactorrhea, Hyperprolactinemia, Mastalgia, Prolactinoma

Supplements: Boswellia (Boswellia serrata), Chasteberry (Vitex agnus castus), Phenylalanine, Tyrosine

Miscellaneous: Dopamine agonists, Pituitary gland

Ayahuasca and Neurodegenerative Disorders.

Posted on April 20, 2010 by Dr. Gary Pack

At this time there is no definitive cure for Parkinson’s disease. In this disease there is a failure of brain cells of the substantia nigra (a location in the brain) to produce dopamine, a neurotransmitter. Parkinsonism can be treated with dopamine agonists or monoamine oxidase (MAO) inhibitor activity, either of which increases dopamine activity. There […]

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Conditions: Alzheimer's disease, Neurodegeneration, Parkinson's disease

Miscellaneous: Amazon, Ayahuasca, Dopamine agonists, Ecuador, Epicatechin, Harmaline, Monoamine oxidase (MAO) inhibitor, Peru, Substantia nigra

Autoimmune Etiology of Generalized Vitiligo.

Posted on October 31, 2009 by Dr. Gary Pack

Vitiligo is an autoimmune disease with the skin melanocyte cells being the immune target. The result is poor skin pigmentation (hypopigmentation.) The melanocyte cells are especially sensitive to immune attack. They contain the free radical scavenging molecule, melanin, and other molecules which are the targets of immune attack in melanoma skin cancer and vitiligo. More […]

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Conditions: Autoimmune disease, Autoimmune thyroiditis, Hypopigmentation, Melanoma, Vitiligo

Supplements: Boswellia (Boswellia serrata), Chasteberry (Vitex agnus castus), Phenylalanine, Tyrosine

Miscellaneous: 5-lipoxygenase inhibitors, Dopamine agonists, Melanin, Melanocytes, Proton pump inhibitors

Biomarkers in Autoimmune Diseases..

Posted on December 20, 2008 by Dr. Gary Pack

Autoimmune diseases can result from hormonal, immune and metabolic processes. This study was done to determine levels of prolactin (PRL), ferritin, vitamin D and tumor marker tissue polypeptide antigen (TPA) in autoimmune diseases, such as systemic lupus erythematosus (SLE), systemic sclerosis (SSC), rheumatoid arthritis (RA), polymyositis (PM), dermatomyositis (DM), multiple sclerosis (MS), antiphospholipid syndrome and […]

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The Role of Prolactin- and Endometriosis-Associated Infertility.

Posted on February 15, 2008 by Dr. Gary Pack

This is a review of hyperprolactinemia or hyperprolactinaemia (high blood prolactin) in endometriosis-related infertility. The fact of their connection is known; but, the definite cause of the relationship between high prolactin (PRL) levels and infertility is not known. This article is a review of the current literature on the subject. PRL is known to have […]

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Conditions: Breastfeeding, Endometriosis, Hyperprolactinemia, Infertility

Supplements: Boswellia (Boswellia serrata), Chasteberry (Vitex agnus castus), Phenylalanine, Tyrosine

Miscellaneous: 5-lipoxygenase inhibitors, Dopamine agonists, Pituitary gland, Prolactin

Chaste Tree (Vitex Agnus-Castus.)

Posted on January 10, 2008 by Dr. Gary Pack

Chaste tree (Vitex agnus castus) fruit extracts have been shown to reduce premenstrual symptoms of breast pain and swelling (mastodynia) and other premenstrual mental and physical symptoms. Large amounts of prolactin are produced premenstrually and are probably the cause of mastodynia. Prolactin levels are increased by pituitary tumors(prolactinomas) during stress and in certain stages of […]

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Conditions: Autoimmune disease, Depression, Hyperprolactinemia, Irritability, Premenstrual syndrome, Prolactinoma, Sleep, Stress

Supplements: Chasteberry (Vitex agnus castus), Coleus (Coleus forskohlii)

Miscellaneous: Clerodadienols, Diterpene, Dopamine, Dopamine agonists, Forskolin (Coleonol), Pituitary gland, Prolactin

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