Fucoidan and Cancer.

Posted on July 9, 2015 by Dr. Gary Pack

In spite of the wide variety of cancer types, there a few basic mechanisms in their cellular behaviors. Most cancers develop because of acquired genetic changes allowing cancer cells to have survival advantages. To survive the ability to develop new blood vessels (angiogenesis) is necessary, and cancers usually develop the ability to metastasize. Poor immunity […]

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Non-Cancer Uses for Histone Deacetylase Inhibitors.

Posted on April 27, 2015 by Dr. Gary Pack

The DNA genetic material of cells changes configuration when undergoing reproduction and repair. As a result, the chromatin* fibers of DNA become more open to chemical changes. These changes occur due to methylation (addition of a methyl group) of the DNA and acetylation (change of an acetyl group). The amount of acetylation is due to […]

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Resveratrol and Cancer.

Posted on July 12, 2013 by Dr. Gary Pack

Resveratrol (Rsv) is a polyphenol found in grape skin, red wine, bilberries, blackberries and other foods. Resveratrol is chemopreventive of some cancers, atherosclerosis, aging and inflammatory diseases. The researchers studied the effects of Rsv on a line of heart muscle tumor cells from mice. Cancers of heart muscles are rare, but cannot be removed easily. […]

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Conditions: Aging, Apoptosis, Arteriosclerosis (atherosclerosis), Cancer, Cell death, Chemotherapy, Heart disease, Heart muscle cancer, Inflammation, Irradiation

Supplements: Resveratrol

Foods: Bilberry, Blackberry, Functional food, Grapes, Red wine

Miscellaneous: Chemoprevention, Muscle, Neurotransmitters, Norepinephrine, Nutraceuticals, Polyphenols

Apoptosis and Necrosis.

Posted on October 13, 2012 by Dr. Gary Pack

Apoptosis is an “intricate, programmed pathway of cell death”, which is considered to be a more natural form of cell death as compared to necrosis. In apoptosis, the following steps are seen: Cell shrinkage. Condensation of nucleus contents. DNA fragmentation. In contrast to apoptosis, cell death seen with injury to the cell (necrosis) includes swelling […]

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Conditions: Apoptosis, Cell death, DNA damage, Inflammation, Necrosis

Supplements: Phosphatidylserine (PS)

Miscellaneous: Phospholipids, Sphingomyelin, Tumor Necrosis Factor (TNF)

Cell Phones and Blood Cell Death.

Posted on July 19, 2012 by Dr. Gary Pack

To read the author’s abstract of the article, click on the title of the article. Then, to read the full article, click on the full text icon. KEY WORDS: Apoptosis, Carotenoid, Cell (mobile) phone, Mitochondria, Mononuclear cell, Oxidative stress, Peripheral blood, Radiation (irradiation), Radiofrequency electromagnetic force, Reactive oxygen species, Self-protection. PMID: 22778799. Summary #818.

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Conditions: Apoptosis, Cell death

Supplements: Carotenoids

Miscellaneous: Electromagnetic fields (EMF), Mitochondria, Mobile phone, Mononuclear blood cells, Radiation, Reactive oxygen species, RF-EMFs

Herbs to Protect Liver From Roundup Herbicide.

Posted on June 16, 2011 by Dr. Gary Pack

Roundup herbicide (glyphosate)-related products are widely used. These chemicals can cause liver damage. They stay in the soil, water and genetically modified (GM) plants, which don’t die because they are resistant to Roundup. The chemicals are consumed by humans when they eat GM plants that have been sprayed with Roundup. The residues, stable in rivers […]

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Conditions: Apoptosis, Cell death, Cytotoxic, Detoxification, Glyphosate (Roundup) poisoning, Liver toxicity

Supplements: Barberry (Berberis vulgaris), Burdock (Arctium lappa), Dandelion (Taraxicum officinale)

Miscellaneous: Genetically modified organisms (GMOs), Herbicides, Roundup herbicide (glyphosate)

Apoptosis and Proliferation by Tribulus Terrestris.

Posted on July 30, 2010 by Dr. Gary Pack

This study was done to learn about the anticancer effects of the saponins in Tribulus terrestris (TT) on normal human skin cells (fibroblasts) in the test tube. TT has been used to improve physical activity and sexual function in men. Saponins have anticancer effects. The anticancer effects of TT must be compared to the effects […]

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Conditions: Aging, Apoptosis, Breast cancer, Cell death, Erectile dysfunction, Hepatoma, Melanoma, Oral cancer, Ovarian cancer

Supplements: Puncture vine (Tribulus terrestus)

Foods: Green tea (Camellia sinensis), Mushrooms, Natto, Sake, Soybeans, Wine

Miscellaneous: Anticancer, Fibroblasts, Polyamines, Proliferation, Putrescine, Saponins, Spermidine, Spermine

Grape Seed Extract in Reperfusion Arrhythmias.

Posted on June 19, 2010 by Dr. Gary Pack

Repair of the circulation to heart muscle (myocardium) which is damaged by a blocked blood supply must be rapid for survival. Otherwise, the heart muscle can die. Abnormal heart rhythms can result from the sudden return of circulation and can lead to death. These rhythms are called reperfusion arrhythmias, including ventricular fibrillation (VF) (an extremely […]

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Conditions: Arrhythmia, Cardiomyopathy, Cardiovascular disease, Cell death, Ventricular fibrillation, Ventricular tachycardia

Supplements: Grape seed extract, Proanthocyanidines, Resveratrol

Miscellaneous: Muscle, Na/K pump

Apigenin, Chrysin, and Luteolin are Proteasome Inhibitors in Tumor Cells.

Posted on September 5, 2009 by Dr. Gary Pack

The proteasomes of cells regulate apoptosis (a natural form of cell death for abnormal cells.) Proteasome activity is increased in cancer cells. Proteasome inhibition arrests cell growth and induces apoptosis in abnormal cells. Proteasome inhibition is seen as a useful therapy against cancers such as multiple myeloma and non-Hodgkin’s lymphoma. Because of the toxicity of […]

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Conditions: Apoptosis, Cell death, Colon cancer, Leukemia, Liver cancer, Lung cancer, Multiple myeloma, Non-Hodgkin's lymphoma

Supplements: Bioflavonoids, Chrysin, EGCG (epigallocatechin gallate)

Foods: Coffee, Tea (Camellia sinensis), Wine

Miscellaneous: Anti-inflammatory, Anticancer, Antioxidant, Antiviral, Apigenin, Flavonoids, Luteolin, Proteasome, Proteasome inhibitors

Autoimmunity and Apoptosis-Therapeutic Implications.

Posted on February 28, 2008 by Dr. Gary Pack

The immune system protects us from foreign pathogens and must distinguish between “self” (elements of the body that belong to us) and “non-self”. Pathogens, such as viruses, bacteria, fungi antigens, are “non-self”. Auto-reactive lymphocytes are abnormal cells of the immune system that can destroy “self”. Apoptosis, natural programmed cell death, is a major way that […]

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Conditions: Apoptosis, Autoimmune disease, Bacterial infection, Cell death, Fungal infection, Sjogren's syndrome, Systemic lupus erythematosus, Viral infection

Miscellaneous: Bone marrow, DNA, Immune system, Prolactin, Thymus gland

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