The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D-3), is a possible treatment for myeloid leukemia and other cancers. The drawback is that 1,25D-3 causes the blood levels of calcium to escalate. The authors demonstrated that a polyphenol of rosemary called carnosic acid enhances the effect of the 1,25D-3 so that a lower dose is effective against cancer without raising the blood calcium.
The current study was done using vitamin D and rosemary against a mouse model of myeloid leukemia. In this study the combination was found to be effective in treating myeloid leukemia in mice.
CONCLUSION: Clinical studies on humans remain to be done. The cancer treating potential of 1,25D-3 with the enhancing potential of carnosic acid from rosemary are emphasized by the author.
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