Condyloma acuminata (CA) is a disease causing warts, with increased growth of new blood vessels and increased cell proliferation. This study was done to see if vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are involved in this disease process. Microvascular density (MVD) was used to evaluate the abnormal blood vessel growth seen in these lesions.
CA patients had higher scores on histochemical testing for VEGF and COX-2 than did healthy controls. Levels of COX-2 and VEGF correlated with each other in the lesions. Both VEGF and COX-2 increased as microvascular density increased.
CONCLUSION: VEGF and COX-2 elevations in CA lesions correlate and could be causes of angiogenesis in the warts in the disease.
NOTE: The original article is in Chinese and translation is not available. So, this summary is based on the abstract, only.
The results are based on lab testing of pathology specimens. Clinical studies have not been done in humans. COX-2 inhibitors on the market include Zyflamend, Echinacea, hops and nettles.
VEGF blockers include milk thistle, DIM from cruciferous vegetables, zinc, green tea, glycine and selenium. Read how VEGF contributes to vascular and tumor pathology.
To read the author’s abstract of the article click on the link to the author’s title of the article above.
PMID: 19462903.
Summary #354.
