Loss of colon circulation (ischemia) followed by the return of the circulation (reperfusion), as seen in colon surgery, was studied in mice. The result of ischemia/reperfusion is inflammation with reactive oxygen species (ROS). ROS cause lipid peroxidation with damage to the fatty layers of the cells of the intestinal wall.
The bacteria of the colon play an important role in protecting the colon from these ischemia/reperfusion injuries which occur often with surgery. Control of lipid peroxidation from ROS is a high priority in living cells. Lipid peroxidation can cause DNA damage as well as damage to the fatty layers of the cell walls.
Rose hips have abundant antioxidant polyphenols. They may prevent lipid peroxidation. Also, rose hips contain vitamin C (ascorbic acid), which has antioxidant effects.
Lactobacillus plantarum is a probiotic with enzyme activity towards polyphenols. L. plantarum helps metabolize the polyphenols of rose hips. Interruption of circulation to the colon tissue results in high levels of MDA and reactive oxygen species which cause tissue damage. Addition of L. plantarum reduces MDA levels in colon tissues and reduced Enterobacteria counts. Enterobacteria tend to be inflammatory. (MDA levels correlated with Enterobacteria counts.) When taken together, rose hips and L. plantarum have additive effects in preventing colon damage.
CONCLUSION: This study confirms the theory that rose hips and L. plantarum work synergistically against lipid peroxidation. They may be a useful combination for use in colon and vascular surgery.
NOTE: Malondialdehyde (MDA) is a chemical which reaches high levels in cells which have received oxidative damage. Studies should be done with this combination to see if they work on other inflammatory bowel diseases and conditions.
Read more about L. plantarum.