The authors studied the influence of arabinogalactan-proteins (AGPs) on the white blood cells of mice. AGPs are found in the roots of Baptisia tinctoria, Echinacea purpurea and Echinacea pallida. The ability of AGPs to increase lymphocytes, increase IGM production, increase nitrite production and increase IL-6 production in mice was tested in the lab. The high molecular weight compounds of AGPs are chemically active in stimulating lymphocytes.
Previous studies have shown that AGPs may be of benefit in treating chemotherapy induced low white blood cell counts.
The authors found that Baptisia tinctoria and Echinacea pallida had strong influence on the lymphocyte proliferation and echinacea purpurea had only weak activity. The Baptisia and Echinacea increased nitrites and IL-6 production, probably as the result of macrophage stimulation. Increased Immunoglobulin M (IgM) activity is most likely the result of activation of B-lymphocytes. IgM are active in response to infection. Both Baptisia tinctoria and Echinacea are effective in stimulating immunity, with Baptisia being the most active.
CONCLUSION: The arabinogalactan-proteins (AGPs) found in Baptisia tinctoria and Echinacea pallida have strong influence on the mouse white blood cell activity and increased the immune response, as tested by the authors.
NOTE: The common name of Baptisia tinctoria is Wild Indigo. Echinacea pallida is an unusual variety of Echinacea with different properties than angustifolia and purpurea. Read about the effects of Echinacea and natural killer cells.
Macrophages, lymphocytes and B lymphocytes are different kinds of white cells.
IL-6 and IgM are chemicals involved in immunity. IL-6 is an inflammatory chemical produced by cells. Among other things it promotes the body’s response to stress. IgM is antibody.