Oral diseases, including caries and periodontitis, consist of biofilms* produced by microbes. Biofilms result in microbial resistance so that the microbes are resistant to prescription antibiotics and antifungals. Common mouthwashes and denture cleansers do not remove all biofilms. Even mouthwash products containing chlorhexidine do not remove all biofilms. Thus, new agents are needed to control oral disease.
Carbohydrate derived fulvic acid (CHD-FA)** is water-soluble, colloidal, and has been proposed to have therapeutic effects for humans. FA acid has been reported to be antibacterial and antifungal. It is a part of the humic acid complex and is not expensive. FA from natural sources must be separated from commonly-associated heavy metals.
FA is reviewed by this article as a potent antifungal against C. albicans biofilms which play a part in oral diseases. Fulvic acid is not altered by biofilm resistance. FA is stronger against C. albicans than other anti-fungal products tested. Also, FA is rapidly fungicidal, but does not significantly reduce biofilm biomass. (Lauroyl glucose disrupts C. albicans biofilms by up to 45% and can be combined with FA.) CHD-FA is shown to be a potential novel antiseptic agent for oral candidiasis and other candida biofilm diseases.
CONCLUSION: CHD-FA is a “highly effective novel antiseptic. FA works against C. albicans fungus by disrupting cell membranes”.
NOTE: *Biofilms are thick secretions produced by bacteria and fungi which protect those microorganisms from antibiotics and other treatment which would destroy them.
**Humic acid and fulvic acid are major products produced by the deterioration of peat moss and coal. They are even found in some rivers as the result of deterioration of plant matter. Shilajit is an Ayurvedic remedy which contains humic and fulvic acids from a thick substance that oozes from the Himalaya mountains.
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