There is an increased incidence of gout in lead workers. Chronic lead exposure reduces urate removal by the kidneys. High uric acid is a predictor of gout. Monosodium urate crystals are found in the joint fluid of patients with gout.
Over 100 healthy subjects were tested in this study. Blood lead levels were measured and kidney function was evaluated. Since blood lead levels do not reflect the amount of lead in the body, “total body burden” was evaluated by a method using intravenous EDTA (calcium disodium ethylenediaminetetracetic acid.) Urate levels were measured before and after chelation for removal of lead.
Subjects with gout had the highest lead levels and lowest renal clearance of urates. Non-gout subjects with the highest levels of lead had higher levels of urate and poorer kidney uric acid clearance than subjects with low lead levels. Chelation therapy for removal of lead resulted in reduced levels of urates for all groups.
These results give new evidence for the importance for lead in our environment. This study suggests that lead chelation is a good alternative treatment for hyperuricemia and gout. Lead in the body interferes with nitric oxide production, reducing blood flow to the kidneys. This can be corrected by lead chelation therapy.
CONCLUSION: Long term lead exposure reduces our ability to eliminate urate through the kidneys, even in the generally healthy population. Lead chelation therapy with EDTA improves the elimination of urates in those with high urate levels. Chelation can reduce hyperuricemia and gout in the general population.
NOTE: High purine diets increase uric acid levels and the following foods should be avoided: alcohol (especially beer,) sweetbreads, anchovies, sardines, liver, beef kidneys, brains, meat extracts, herring, mackerel, scallops and game meats.
Plumbum metallicum homeopathic removes lead from the body. Arginine corrects nitric oxide deficiency and improves circulation. Phyllanthus niruri is used to treat hyperuricemia.
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