"Anti-Tumor Activities of Andrographolide, a Diterpene from Andrographis Paniculata, by Inducing Apoptosis and Inhibiting VEGF Level."
Andrographolide is a chemical called a diterpine lactone found in the plant called Andrographis paniculata. This plant has been shown, scientifically, to have anti-inflammatory activity, which is an oriental traditional medicine used to treat inflammation. Injections of derivatives of andrographolide, called Lianbizhi, have been found to inhibit gastric, liver and lung cancers in living patients.
The present study was done to test the anti-cancer effects of andrographolide in the laboratory against several cancer cell lines. Prostate cancer cell growth was inhibited the most and had the most apoptosis, demonstrated by cellular and DNA analysis. The inhibition of cell proliferation was equal to that of cisplatin, a pharmaceutical chemotherapy medication.
Vascular endothelial growth factor (VEGF) is a chemical important in the growth of cancers. Its presence is important in the prognosis of cancer cells since it promotes the growth of new blood vessels (angiogenesis) supplying nutrition and oxygen to tumors. Andrographilide was shown to have a marked inhibitory effect on VEGF release in prostate cancer cells (PC-3 type).
CONCLUSION: Andrographolide, from Andrographis paniculata, is a chemical that has anti-inflammatory activity and has been shown by this study to be effective against several cancer cell lines. It was most effective against a type of prostate cancer cells in which it induced apoptosis and inhibited VEGF.
NOTE: Apoptosis is a programmed type of cell death that has been found to be effective against cancer cells. VEGF is a chemical produced in cancers to cause the growth of new blood vessels, angiogenesis, a process required for cancers to grow. Blocking angiogenesis is another new way to treat cancers. Read about the effect of Andrographis in vascular and tumor biology.
Summary 153 is a review of anti-oxidant studies of Andrographis panniculata, an Ayurvedic herbal preparation known as Kalmegh. Diterpene lactones come from essential oils, gums or resins.
PMID: 18464090.
Summary #252.
Andrographis paniculata, in capsules.
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