"Multifocal Angiostatic Therapy: An Update."
Multifocal Angiostatic Therapy (MAT) is a treatment method that attempts to prevent cancers from growing new blood vessels. Angiogeneis is the growth of new blood vessels and Angiostatic treatments are aimed at slowing cancer growth. Cancers need new blood vessels to grow larger and cancers produce chemicals that change endothelial cells into blood vessel cells. Endothelial cells of tumors have the ability to form tubes that become blood vessels and are the cells that usually line the cavities of the body. The tube formations can become tiny blood vessels called capillaries.
There are oral supplements that slow the growth of these new blood vessels and limit the growth of cancers. Supplements and techniques that have been previously used in MAT to prevent angiogenesis include green tea polyphenols, fish oil, selenium, high-dose glycine, very low-fat vegan diet, aerobic exercise training, and tetrathiomolybdate, which removes copper from the body.
Diindolylmethane (DIM), a product of the metabolism of indole-3-carbinol, crushed from cruciferous vegetables slows cancer growth, possibly due to slowing of blood vessel growth. Cruciferous vegetables include cauliflower, broccoli, brussels sprouts, etc. Commercial DIM is taken in doses up to 400 mg. per day and the author believes that at this level the DIM should have the ability to slow cancer growth.
Silymarin and silibinin, extracts of milk thistle (Silybum marianum), suppress the tube forming capacity of endothelial cells and suppress the secretion of vascular endothelial growth factor (VEGF) by many cancers. VEGF is a chemical that promotes the growth of blood vessels. Milk thistle has the advantage that high blood levels can be obtained by oral administration. Silibinin, the major component of silymarin, has the ability to prevent tube formation by direct action on the endothelial cells. The author suggests the dose of 2.5 gm. of milk thistle silymarin extract per day or 1.5 gm. of silibinin per day.
High dose zinc therapy has an angiostatic effect by reducing the blood levels of copper. Low copper levels in the blood slow angiogenesis. Tetrathiomolybdate (TM) also prevents angiogenesis by reducing copper in the body and it works quickly, but is not available in the retail market. Low levels of copper appear to inhibit a cancer's formation of chemicals that increase tube formation.
Green tea is believed to inhibit the production of VEGF. The polyphenol of green tea extract is epigallocatechingallate (EGCG), but high blood levels of EGCG are difficult to maintain by oral use of green tea. Further studies are needed to see if the usual blood levels of green tea are sufficient to slow cancer growth.
Glycine's activity is angiostatic, due to a hyperpolarizing effect on the plasma membrane of endothelial cells. The plasma membrane is one layer of the cell wall. The hyper polarization of the plasma membrane is angiostatic by some unknown mechanism.
The angiostatic activity of selenium is only seen with high doses of selenium that approach the doses which cause side effects of hair loss and nausea.
A very-low-fat whole-food diet is angiostatic especially when done in combination with aerobic exercise. Fish-oil-rich diets slow the growth of many cancers in rodents.
CONCLUSION: DIM, milk thistle extract, green tea extract, fish oil, glycine, selenium a low-fat vegan diet and exercise are a good program for slowing blood vessel growth and for slowing cancer growth.
NOTE: Dr. William Li has a video on ted.com about blocking vessel growth (anti-angiogenesis) to block the growth of cancers. This treatment can be used to slow the progress of macular degeneration, also. Read a list of natural products and lifestyle changes which are angiostatic.
PMID: 16282507.
Summary #081.
Silymarin (milk thistle extract.)
DIM.
Glycine.
Green tea extracts in liquid and capsules.
Selenium in tablets and capsules.
Zinc.
Fish oil.
To order the above products call 415-863-0620 and ask for "supplements".
You are entering the portion of the website of Rainbow Grocery Cooperative, Inc., that is here "to strive to offer education", as stated in our Mission Statement. Here we are reporting on scientific studies that are about the value of nutritional supplements and whole foods for our health. We will attempt to report on the latest studies regarding the supplements and foods sold at Rainbow Grocery. The summaries of the articles are our own. These summaries are not intended to promote any particular product or food that Rainbow sells, but only to provide information about them.
You are your own best doctor. Study as much as you can. Consult with your doctor. Find one open to alternatives if your doctor isn't. Make your own decisions and take responsibility for your own health. We hope this information will help you make your decisions.
We can't and don't intend to prescribe for you. We can't and don't intend to provide medical advice. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Don't disregard professional medical advice or delay in seeking it because of something you have read on this website.
Nothing in this website is intended to create a health practitioner-patient relationship. Reliance on the information provided on this website is solely at your own risk. In using this web site you agree that neither Rainbow Grocery Cooperative, Inc. nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this web site.
Advertencia sobre el uso de los resúmenes de estudios médicos publicados en este portal:
Usted está entrando a la parte del portal de Internet de la Cooperativa de Rainbow Grocery, Inc. cuyo fin es “procurar ofrecer elementos educativos” tal como lo establece nuestra Declaración de Principios. Lo que aquí se reporta son estudios científicos sobre el valor nutricional de suplementos y alimentos completos para la salud. Trataremos de incluir los estudios más recientes sobre suplementos y productos alimenticios que se expenden en Rainbow Grocery. Los resúmenes de los artículos han sido elaborados por nosotros. Pero su inclusión no tiene como fin promover productos específicos que se venden en Rainbow, sino sólo proporcionar información sobre los mismos.
Usted es su mejor doctor. Estudie e infórmese tanto como le sea posible. Consulte a su médico. Busque uno de mente abierta a alternativas si el actual no lo es. Tome sus propias decisiones y hágase responsable de su salud. Esperamos que la información aquí presentada le ayude a tomar las mejores decisiones.
No podemos ni es nuestra intención ofrecer recetas o proporcionar asesoría médica. Usted siempre debe consultar con su médico u otro proveedor profesional de servicios de salud cuando tenga preguntas relacionadas con su salud. No ignore los consejos profesionales de su médico, ni deje de buscarlos en base a lo que haya leído en nuestro portal.
Nada en este portal tiene la finalidad de crear una relación paciente-profesional de la salud. El uso de la información aquí presentada es bajo su cuenta y riesgo. Al usar este portal, usted acepta que ni la Cooperativa de Rainbow Grocery, Inc. ni tercera partes son responsables de forma alguna por cualquier decisión tomada o acción ejecutada en base al uso de la información presentada en este portal.
